These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of resistance training on insulin-like growth factor and its binding proteins in men and women aged 60 to 85.
    Author: Borst SE, Vincent KR, Lowenthal DT, Braith RW.
    Journal: J Am Geriatr Soc; 2002 May; 50(5):884-8. PubMed ID: 12028176.
    Abstract:
    OBJECTIVES: We have reported that resistance training (RT) elevates insulin-like growth factor (IGF-I) in healthy young adults. Our goals were to determine whether RT produces a similar effect in the healthy older persons and to determine the effects of low- versus high-intensity RT on hormonal status. SETTING: Center for Exercise Science, University of Florida, Gainesville. PARTICIPANTS: Sixty-two men and women (mean age = 68.1). INTERVENTION: A 6-month, 3-day/week program of low-intensity RT (LEX), high-intensity RT (HEX), or no exercise (CON). MEASUREMENTS: Before and after training, blood was drawn for hormone analysis. IGF-I, IGF binding protein-1 (IGFBP-1), and IGFBP-3 were measured at rest. Testosterone and cortisol were measured at rest and immediately after exercise. RESULTS: RT caused significant increases in 1-repetition maximum (1RM) strength and peak oxygen consumption (V02peak), which we have reported separately. Currently, we report that RT had no effect on the resting serum concentrations of IGF-I, IGFBP-1, IGFBP-3, testosterone, or cortisol. Acute resistance exercise caused no change in circulating testosterone in men or women but did cause a significant elevation of cortisol in the HEX group. This increase in cortisol was blunted as a result of training. CONCLUSIONS: We conclude that the increases in strength and endurance caused by RT were not mediated by increases in circulating IGF-I, IGFBPs, or testosterone.
    [Abstract] [Full Text] [Related] [New Search]