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  • Title: [Male hypogonadotropic hypogonadism. Success of treatment of sterility with HMG plus HCG].
    Author: Gayral MN, Millet D, Mandelbaum J, Serfaty D, Netter A.
    Journal: Ann Endocrinol (Paris); 1975; 36(4):211-2. PubMed ID: 1203013.
    Abstract:
    Ten typical cases of male eunuchoidism (two with anosmia) are reported. After administration of clomifene citrate to five patients, there is no change in blood levels of gonadotrophins in four cases; in the fifth, a small and transitory increase of LH is noted. The intravenous injection of LHRH (100 mug) to five patients induces an increase of serum LH in all cases and serum FSH in three cases. The initial site of the dysfunction is possibly hypothalamic with secondary gonadotrophic pituitary insufficiency. Among six patients anxious for paternity, prolonged treatment (for 36 to 98 weeks), with HCG (250-1 000 I.U. daily) +HMG (65-120 I.U. FSH daily) results in appearance of spermatozoa in the seminal fluid in five cases and a pregnancy was obtained in four cases. Comments are done upon methods of treatment.
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