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  • Title: BRL 37344 inhibited adrenergic transmission in the rat portal vein via atypical beta-adrenoceptors.
    Author: Yousif MH, Oriowo MA.
    Journal: Pharmacol Res; 2002 Apr; 45(4):313-7. PubMed ID: 12030795.
    Abstract:
    The effect of BRL 37344, a beta(3)-adrenergic agonist on adrenergic transmission in isolated segments of the rat portal vein was examined in this study. BRL 37344 (10(-9) - 10(-5)M) produced concentration-dependent inhibition of electrically induced contractions. This inhibitory effect of BRL 37344 was not antagonized by propranolol ( 10(-6)M). Isoprenaline ( 10(-9) - 10(-4)M) also produced a concentration-dependent inhibition of electrically induced contractions in the portal vein. Propranolol (10(-6)M) antagonized isoprenaline responses with a -logK(B) value of 8.14 +/- 0.32. BRL 37344-induced inhibition of electrically induced contractions was also unaffected by cyanopindolol (10(-6)M). Isoprenaline but not BRL 37344 significantly reduced noradrenaline-induced contractions of the rat portal vein. CGP12177A produced propranolol-resistant inhibition of electrically induced contractions of the rat portal vein. It was therefore concluded that BRL 37344 inhibited adrenergic transmission in the rat portal vein via atypical beta -adrenoceptors located prejunctionally.
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