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  • Title: Mg++SO4 treatment improves the hemodynamics following the acute myocardial ischemia and reperfusion.
    Author: Karapinar K, Ulus AT, Kaplan S, Tütün U, Saritas A, Aksöyek A, Apaydn N, Saritas Z, Katircioglu SF.
    Journal: Panminerva Med; 2002 Jun; 44(2):129-33. PubMed ID: 12032431.
    Abstract:
    BACKGROUND: The effect of Mg++SO4 on myocardial hemodynamics was investigated in this study. METHODS: Twelve dogs were entered in this research. Six dogs received Mg++SO4 and the remaining dogs were considered as controls. The amount of Mg++SO4 that was administered to the animals was 0.15 mmol/kg/hr each. The left anterior descending artery was occluded for a period of 1 hour and the drug was administered during reperfusion. RESULTS: Two hours after reperfusion, cardiac output was 1275+/-50 ml/min in the control group and 1475+/-25 ml/min in the Mg++SO4 group (p<0.05), pulmonary capillary wedge pressure was 18+/-3 mmHg in the control group and 12+/-2 mmHg in the Mg++SO4 group. CONCLUSIONS: In this study it was shown that Mg++SO4 usage after 1 hour arterial occlusion and 2 hours reperfusion protects the heart from the adverse effects of ischemia/reperfusion and had a better central hemodynamics.
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