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  • Title: Initial activation of cyclin-B1-cdc2 kinase requires phosphorylation of cyclin B1.
    Author: Peter M, Le Peuch C, Labbé JC, Meyer AN, Donoghue DJ, Dorée M.
    Journal: EMBO Rep; 2002 Jun; 3(6):551-6. PubMed ID: 12034754.
    Abstract:
    At the G(2)/M transition of the cell cycle, the cdc25c phosphatase dephosphorylates inhibitory residues of cdc2, and cyclin-B-cdc2 kinase (MPF) is activated. Phosphorylation of cyclin B1 induces its nuclear accumulation, and, since cdc25c is also believed to accumulate and activate shortly before G(2)/M in the nucleus, it has been proposed that this induces cyclin-B1-cdc2 kinase activation. We demonstrate that cyclin B1 phosphorylation has another essential function in vivo: it is required for cdc25c and MPF activation, which does not require nuclear accumulation of cyclin B1, and occurs in the cytoplasm.
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