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  • Title: Frequency of functional interleukin-10 promoter polymorphism is different between relapse-onset and primary progressive multiple sclerosis.
    Author: de Jong BA, Westendorp RG, Eskdale J, Uitdehaag BM, Huizinga TW.
    Journal: Hum Immunol; 2002 Apr; 63(4):281-5. PubMed ID: 12039409.
    Abstract:
    Interleukin-10 (IL-10) secretion affects the inducibility of experimental autoimmune encephalomyelitis and the outcome of multiple sclerosis (MS). Here, we report that a G to A polymorphism in the IL-10 promoter at position -2849 is significantly associated with low IL-10 production. The frequency of this polymorphism is lower among patients with primary progressive compared with patients with relapse-onset MS and control persons.
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