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  • Title: Comparison of polyethylene glycol 3350 and lactulose for treatment of chronic constipation in children.
    Author: Gremse DA, Hixon J, Crutchfield A.
    Journal: Clin Pediatr (Phila); 2002 May; 41(4):225-9. PubMed ID: 12041718.
    Abstract:
    Polyethylene glycol (PEG) 3350 and lactulose were compared in an unblinded, randomized, crossover design for treatment of constipation in 37 children aged 2 to 16 years. Subjects received lactulose (1.3 g/kg/d divided twice daily up to 20 g) or PEG 3350 (10 g/m2/day) for 2 weeks. PEG 3350 significantly decreased the total colonic transit time compared to lactulose (47.6+/-2.7 vs 55.3+/-2.4 hours, mean +/- SE, PEG 3350 vs lactulose, respectively, p = 0.038). The stool frequency, form, and the ease of passage were similar for each laxative. Polyethylene glycol 3350 is an effective laxative for the treatment of chronic constipation in children.
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