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  • Title: Imipenem/cilastatin as empirical treatment of severe infections in compromised patients.
    Author: Biglino A, Bonasso M, Gioannini P.
    Journal: J Chemother; 1991 Jan; 3 Suppl 1():208-12. PubMed ID: 12041767.
    Abstract:
    Imipenem/cilastatin was administered as empirical treatment to 22 patients with severe infections, at dosages of 2 or 4 g/day, either alone or in combination with an aminoglycoside. The majority of patients had underlying diseases causing various degrees of immune system dysfunction. The overall cure rate was 77.2%, without significant differences according to the type of pathogen or dosage schedule; however one of the two observed failures was due to a resistant Pseudomonas aeruginosa. Strains recovered from improved patients were all sensitive to the drug. Only mild adverse effects were evidenced, without any alteration of laboratory parameters. Imipenem/cilastatin may be useful as monotherapy in empirical treatment of severe infections in compromised patients.
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