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  • Title: Release of gamma-[(3)H]aminobutyric acid in rat brain cortical slices by alpha-scorpion toxin.
    Author: Nicolato R, Fernandes VM, Moraes-Santos T, Gomez RS, Prado MA, Romano-Silva MA, Gomez MV.
    Journal: Neurosci Lett; 2002 Jun 14; 325(3):155-8. PubMed ID: 12044644.
    Abstract:
    In this paper, the effect of the alpha-scorpion toxin tityustoxin (TsTX) in the release of gamma-[(3)H]aminobutyric acid ([(3)H]GABA) from rat brain cortical slices is described. The TsTX-stimulatory effect on the release of [(3)H]GABA was dependent on incubation time and TsTX concentration, having an EC(50) of 0.33 microM. Tetrodotoxin (TTX) completely inhibited the TsTX action on [(3)H]GABA release. The scorpion toxin effect was calcium-dependent and involves P/Q calcium channels. beta-Alanine also induces the release of [(3)H]GABA that was not inhibited by TTX but was additive in the presence of TsTX. The data suggest a neuronal origin for the release of [(3)H]GABA by TsTX.
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