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  • Title: Bioactivity of alkamides isolated from Echinacea purpurea (L.) Moench.
    Author: Clifford LJ, Nair MG, Rana J, Dewitt DL.
    Journal: Phytomedicine; 2002 Apr; 9(3):249-53. PubMed ID: 12046867.
    Abstract:
    Alkamides from the roots of Echinacea purpurea (L.) Moench were examined for anti-inflammatory activity in an in vitro model system. Cyclooxygenase-I (COX-I) and cyclooxygenase-II (COX-II) inhibitory activities were assessed at pH 7 for alkamides isolated from E. purpurea roots to compare inhibitory activities between the two cyclooxygenase isozymes. At 100 microg/ml, several E. purpurea alkamides inhibited COX-I and COX-II enzymes in the range of 36-60% and 15-46%, respectively, as compared to controls. Mosquitocidal activity was assessed at 100 and 10 microg/ml, with 100% mortality against Aedes aegyptii L. larvae noted for several E. purpurea alkamides at 100 microg/ml.
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