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  • Title: Protein-interaction networks: from experiments to analysis.
    Author: Schächter V.
    Journal: Drug Discov Today; 2002 Jun 01; 7(11):S48-54. PubMed ID: 12047880.
    Abstract:
    Functional proteomics approaches aim to characterize comprehensively the function of gene products, and provide a first-level understanding of cellular mechanisms. Here, we review recent techniques for the construction and prediction of large-scale protein-interaction networks, with a particular emphasis on computational processing steps and comparative assessment of the reliability and completeness of the various approaches. We also discuss the use of protein-interaction network information in functional annotation and in the generation of higher-level biological hypotheses on pathways.
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