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  • Title: Utility of micral test strips in screening for microalbuminuria.
    Author: Gossain VV, Gunaga KP, Carella MJ, Edminster RR, Bowman KA, Rovner DR.
    Journal: Arch Pathol Lab Med; 1996 Nov; 120(11):1015-8. PubMed ID: 12049101.
    Abstract:
    OBJECTIVE: To evaluate the clinical utility of Micral strips for detection of microalbuminuria. DESIGN: One hundred three urine samples were tested by Micral strips for the presence of microalbuminuria, and the results were compared with the immunonephelometric method. SETTING: Endocrine diabetes clinic in a university-affiliated outpatient facility and the associated clinical laboratory. PATIENTS: Sixty-seven, 24-hour urine samples were obtained from 64 patients with diabetes. Thirty-six urine samples were obtained from normal controls; 22 of these were 24-hour samples and 14 were overnight samples. MAIN OUTCOME MEASURE: Concordance of results obtained by the two methods for the presence or absence of microalbuminuria. RESULTS: All 36 control subjects and 44 urine samples from diabetic patients had normal albumin excretion (<15 mg/24 h) by the immunonephelometric method. Seventy-eight of these were correctly identified as negative by Micral strips, giving a specificity of 97.5%. There were 23 samples with albumin excretion of more than 16 mg/24 h. Sixteen of these were correctly identified, giving a sensitivity of 69.5%. There were 16 samples with albumin excretion of 30 mg/24 h or more; 14 of these were correctly identified by Micral strips, and two were false negatives, giving a sensitivity of 87.7%. However, when urine samples with albumin concentrations of less than 11 mg/L were excluded, the Micral strips correctly read 21 out of 23 samples, giving a sensitivity of 91.3%. CONCLUSIONS: The specificity of Micral strips for detection of albuminuria in 24-hour urine samples is high (97.5%), but the sensitivity is low, ranging from 69.5% to 87.7%. The sensitivity was greatly improved when urine samples with albumin concentrations of less than 11 mg/L were excluded.
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