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  • Title: [Clinical evolution of a cohort of patients with Graves-Basedow disease treated with metimazole].
    Author: De Luis DA, Arconada A, Aller R, Cuéllar LA, Terroba MC, Martín Gil J.
    Journal: Med Clin (Barc); 2002 Jun 01; 118(20):777-8. PubMed ID: 12049693.
    Abstract:
    BACKGROUND: Prospective studies of Graves-Basedow disease in Spain are scarce. Our objective was to evaluate the clinical and biochemical evolution of a cohort of patients with Graves-Basedow disease. PATIENTS AND METHOD: 202 patients with Graves-Basedow disease diagnosed between January 1997 and June 1999. RESULTS: 5.9% of patients received 131I and 2.5% underwent surgery after treatment with methimazole. A relapse was observed in 23.3% patients. In the survival analysis, significant differences with regard to the rate of relapse were observed according to the goitre degree. CONCLUSIONS: In our study, all patients reached remission with methimazole. There was a high rate of relapse following discontinuation of therapy within the first months. Goitre size at the time of diagnosis was a significant determining factor of relapse.
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