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  • Title: Recent advances in understanding aminoglycoside ototoxicity and its prevention.
    Author: Wu WJ, Sha SH, Schacht J.
    Journal: Audiol Neurootol; 2002; 7(3):171-4. PubMed ID: 12053140.
    Abstract:
    Studies over the last decade have left little doubt that reactive oxygen species (ROS) participate in the cellular events leading to aminoglycoside-induced hearing loss. The evidence ranges from the demonstration of aminoglycoside-mediated ROS formation in vitro to the prevention of ototoxicity by antioxidants in guinea pig in vivo. Here we review a hypothesis of the mechanism of toxicity, discuss possible causes underlying the gradient in base-to-apex sensitivity of outer hair cells, and present recent results on the adult mouse as a new animal model of aminoglycoside ototoxicity and its prevention.
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