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  • Title: Ammonia detoxification by continuous venovenous haemofiltration in an infant with urea cycle defect.
    Author: Chan WK, But WM, Law CW.
    Journal: Hong Kong Med J; 2002 Jun; 8(3):207-10. PubMed ID: 12055368.
    Abstract:
    We report the case of a newborn baby with carbamoyl phosphate synthetase deficiency. He presented at 2 weeks of life, deteriorating to a state of hyperammonaemic coma and respiratory failure. Rapid detoxification was successfully achieved by continuous venovenous haemofiltration while a definitive diagnosis and treatment were determined. The ammonia clearance achieved by continuous venovenous haemofiltration was greater than 20 mL/min/m(2), which is superior to that achieved by peritoneal dialysis and arteriovenous haemofiltration in this age-group.
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