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  • Title: NMR studies of CCK-8/CCK1 complex support membrane-associated pathway for ligand-receptor interaction.
    Author: Giragossian C, Pellegrini M, Mierke DF.
    Journal: Can J Physiol Pharmacol; 2002 May; 80(5):383-7. PubMed ID: 12056543.
    Abstract:
    The interaction of peptide ligands with their associated G-protein-coupled receptors has been examined by a number of different experimental approaches over the years. We have been developing an approach utilizing high-resolution NMR to determine the structural features of the peptide ligand, well-designed fragments of the receptor, and the ligand-receptor complexes formed upon titration of the peptide hormone. The results from these investigations provide evidence for a membrane-associated pathway for the initial interaction of peptide ligands with the receptor. Here, our results from the investigation of the interaction of CCK-8 with the CCK1 receptor are described. Our spectroscopic results clearly show that both CCK-8 and the regions of CCK1 with which it interacts are closely associated with the zwitterionic interface of the lipids utilized in our solution spectroscopic studies.
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