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  • Title: Are PhAcOZ and Nsc suitable N alpha-protecting groups for protease-catalysed peptide synthesis?
    Author: Braun K, Kuhl P.
    Journal: Pharmazie; 2002 May; 57(5):310-2. PubMed ID: 12061253.
    Abstract:
    Protecting groups are necessary chemical tools in peptide synthesis. In protease-catalysed peptide synthesis they exert influence both on enzyme-substrate binding and on solubility. In this study, we have investigated the usability of various PhAcOZ- and Nsc-protected amino acids for protease-catalysed peptide synthesis. PhAcOZ-protected peptides were obtained in high yields using papain and thermolysin. In contrast to this, Nsc, as a base-labile alpha-amino protecting group, is not suitable for biocatalytic synthesis under the conditions employed.
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