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  • Title: Nuclear Apaf-1 and cytochrome c redistribution following stress-induced apoptosis.
    Author: Ruiz-Vela A, González de Buitrago G, Martínez-A C.
    Journal: FEBS Lett; 2002 Apr 24; 517(1-3):133-8. PubMed ID: 12062423.
    Abstract:
    Apoptotic protease activating factor-1 (Apaf-1) and cytochrome c are cofactors critical for inducing caspase-9 activation following stress-induced apoptosis. One consequence of caspase-9 activation is nuclear-cytoplasmic barrier disassembly, which is required for nuclear caspase-3 translocation. In the nucleus, caspase-3 triggers proteolysis of the caspase-activated DNA nuclease (CAD) inhibitor, causing CAD induction and subsequent DNA degradation. Here we demonstrate that apoptotic cells show perinuclear cytochrome c aggregation, which may be critical for nuclear redistribution of cytochrome c and Apaf-1. We thus indicate that the nuclear redistribution of these cofactors concurs with the previously reported caspase-9-induced nuclear disassembly, and may represent an early apoptotic hallmark.
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