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  • Title: [Ways of overcoming drug resistance in patients with pulmonary tuberculosis].
    Author: Grishin MN, Svistov VV, Krivoshein IuS.
    Journal: Probl Tuberk; 2002; (3):16-8. PubMed ID: 12066525.
    Abstract:
    To elucidate the combined effect of surfactants and antituberculous drugs, the surfactant myrastimine was tested. Two series of sputum cultures with multidrug-resistant Mycobacterium tuberculosis (MBT) strains were made. The experimental results confirmed that myramistine noticeably enhanced the sensitivity of multidrug-resistant MBT strains to antituberculous agents. The use of endobronchial and intracavernous myramistine in combination with antituberculous agents to patients with destructive pulmonary tuberculosis caused by multidrug-resistant MBT strains reduced the latter's resistance to antibiotics, cured tubendobronchitis in most patients, created conditions for obliteration of the cavernous cavity. Positive changes are noted in the first 4 months after the initiation of therapy, which can prepare patients for surgical treatment more rapidly.
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