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  • Title: Stimulation of erythropoietic differentiation in BALB/c mice infected with Rauscher leukemia virus.
    Author: Weitz-Hamburger A, Fredrickson TN, LoBue J, Hardy WD, Camiscoli JF, Ferdinand P, Gallicchio V, Gordon AS.
    Journal: J Natl Cancer Inst; 1975 Nov; 55(5):1171-5. PubMed ID: 1206743.
    Abstract:
    The function of phenylhydrazine (PHZ) hemolysis in ameliorating the anemia induced in mice by a slow-acting strain of Rauscher leukemia virus (RLV-A) was described. After cessation of treatment with PHZ, mid-stage RLV-A-infected, anemic mice responded with massive reticulocytoses and a rebound in hematocrit above control levels. RLV-infected mice, subjected to PHZ-induced hemolysis or phlebotomy, produced high levels of plasma erythropoietin (Ep); this suggested that Ep mediated the PHZ-induced differentiation. In addition, administration of exogenous Ep induced a wave of erythroid maturation in RLV-infected anemic mice, which indicated that virus-infected erythroid precursors could still respond to the hormone governing normal differentiation.
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