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  • Title: Differentiation of melanocytes in cultures of primary malignant melanoma indicated by 5-S-cysteinyldopa formation.
    Author: Aubert C, Rosengren E, Rorsman H, Rougé F.
    Journal: J Natl Cancer Inst; 1975 Dec; 55(6):1327-8. PubMed ID: 1206755.
    Abstract:
    The dedifferentiation of cultured primary human malignant melanocytes was not accompanied by disappearance of 5-S-cysteinyldopa formation. The addition of conditioned medium from undifferentiated fibroblast-like cells brought about the reappearance of pigmented melanocytes and the increase of the metabolite in the cells and culture medium. The presence of 5-S-cysteinyldopa in cultured cells indicated the melanocytic origin of undifferentiated cells, and the increase of this metabolite was characteristic of differentiation.
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