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  • Title: [Atypical Cogan syndrome. Clinical and laboratory spectrum. Report of 2 cases].
    Author: García Callejo FJ, Platero Zamarreño A, Sebastián Gil E, Orts Alborch MH, Marco Algarra J.
    Journal: Acta Otorrinolaringol Esp; 2002 Mar; 53(3):191-8. PubMed ID: 12073679.
    Abstract:
    We show two atypical Cogan's syndrome cases in forty-seven and fifty-six years old individuals. Characteristical symptoms of the syndrome were detected in both (interstitial keratitis, sensorineural deafness and vestibular dysfunction), but they could be considered as unusual because of the association of systematic symptoms and an onset with hearing loss. In both cases there was an increase in erythrosedimentation rate and immunoglobulins levels, as well as high titles for rheumatoid factor and non-specific autoantibodies. By means of a Western-blot technique, several chochlear antibodies with distinct molecular weight were detected, but the 68 KD appeared in both. Metil-prednisolone treatment did not avoid ocular and auditive reactivation in ne of the patients.
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