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  • Title: Downstream targets of let-60 Ras in Caenorhabditis elegans.
    Author: Romagnolo B, Jiang M, Kiraly M, Breton C, Begley R, Wang J, Lund J, Kim SK.
    Journal: Dev Biol; 2002 Jul 01; 247(1):127-36. PubMed ID: 12074557.
    Abstract:
    In Caenorhabditis elegans, let-60 Ras controls many cellular processes, such as differentiation of vulval epithelial cells, function of chemosensory neurons, and meiotic progression in the germ line. Although much is known about the let-60 Ras signaling pathway, relatively little is understood about the target genes induced by let-60 Ras signaling that carry out terminal effector functions leading to morphological change. We have used DNA microarrays to identify 708 genes that change expression in response to activated let-60 Ras.
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