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  • Title: Identification of signal peptide peptidase, a presenilin-type aspartic protease.
    Author: Weihofen A, Binns K, Lemberg MK, Ashman K, Martoglio B.
    Journal: Science; 2002 Jun 21; 296(5576):2215-8. PubMed ID: 12077416.
    Abstract:
    Signal peptide peptidase (SPP) catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. In humans, SPP activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. We have identified human SPP as a polytopic membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. SPP and potential eukaryotic homologs may represent another family of aspartic proteases that promote intramembrane proteolysis to release biologically important peptides.
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