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  • Title: Effects of Roxithromycin on the production of lipase and neutrophil chemotactic factor by Propionibacterium acnes.
    Author: Akamatsu H, Tomita T, Horio T.
    Journal: Dermatology; 2002; 204(4):277-80. PubMed ID: 12077521.
    Abstract:
    BACKGROUND: The macrolide antibiotic roxithromycin is effective against acne associated with inflammation, but the mechanism by which this is achieved has not been clarified. OBJECTIVE: We studied the effects of roxithromycin on the production of lipase and neutrophil chemotactic factor by Propionibacterium acnes in vitro. RESULTS: Roxithromycin significantly inhibited the production of lipase and neutrophil chemotactic factor by P. acnes at a concentration one eighth of the MIC, at which the growth curve of P. acnes is not affected. CONCLUSION: One mechanism of the effectiveness of roxithromycin in acne therapy is thought to be the inhibition of bacterial lipase and neutrophil chemotactic factor production by P. acnes.
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