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  • Title: [The effects of TGF-beta on the proliferation and differentiation of human osteoblast-like cells].
    Author: Tian W, Wang D.
    Journal: Hua Xi Kou Qiang Yi Xue Za Zhi; 1998 Feb; 16(1):65-8, 72. PubMed ID: 12078191.
    Abstract:
    Osteoblast-like cells were isolated from embryonic human calvarium with modified enzyme digestion method. TGF-beta which is believed having biological effects on bone cells was added into the culture medium with separate concentrations. The incorporation of 3H-TdR, 3H-Proline of osteoblast-like cells and alkaline phosphatase(ALP) content of the cells were tested to study the effects of the TGF-beta on the proliferation of osteoblasts. The results showed that TGF-beta increased ALP activity and the synthesis of collagen, and the cell proliferation was inhibited. It affected the proliferation and differentiation of osteoblast-like cells with the best 1 ng/ml among four concentration of 0.01-10 ng/ml. These findings suggested that function of TGF-beta might be modified by other local growth factors.
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