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  • Title: [The effects of IGF-II on the proliferation and differentiation of human osteoblast-like cells].
    Author: Tian W, Wang D.
    Journal: Hua Xi Kou Qiang Yi Xue Za Zhi; 1998 Feb; 16(1):69-72. PubMed ID: 12078192.
    Abstract:
    Biological regulatory mechanism which supports bone cell development within the context of proliferation/differentiation relationship serves as a viable basis for addressing skeletal disorders and provides experiment and theoretic basis for selection and utilization of growth factors to reconstruct bone defect. Osteoblast-like cells isolated from human calvarium were used in this study. IGF-II were investigated by adding in the culture medium with different concentration. The results showed that IGF-II stimulated DNA, collagen synthesis and ALP activity of human osteoblast-like cells. Its effects were strong for proliferation and differentiation of osteoblast cells, when 10 ng/ml of four different concentrations (0.1, 1, 10 and 100 ng/ml) were used. IGF-II was proved to be important factor in bone regeneration.
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