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  • Title: [Studies on cathepsins in Schistosoma japonicum].
    Author: Li Y, Fen Y, Caffrey C, Ruppel A.
    Journal: Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi; 1998; 16(2):101-4. PubMed ID: 12078215.
    Abstract:
    AIM: To identify the cathepsins in adult worms of Schistosoma japonicum and their proteolytic activities. METHODS: The vomitus from adult worms of S. japonicum was collected. The proteolytic activity of cathepsins in the vomitus was identified and measured using synthetic substrates with arginyl bonds. RESULTS: Specific synthetic subtracts Z-Arg-Arg-AMC (for cathepsin B) and Z-Phe-Arg-AMC (for cathepsin B and L) were degraded by the vomitus. An inhibitor, Z-Phe-PheCHN2 for cathepsin L, inhibited partially the activity of the vomitus to degrade Z-Phe-Arg-AMC. The optimal pH for cathepsin B/L is 5.0-5.5. CONCLUSION: The vomitus of S. japonicum has cathepsin B- and L-like activity.
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