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  • Title: [Measuring beta-trace protein for detection of perilymph fistulas].
    Author: Bachmann G, Petereit H, Djenabi U, Michel O.
    Journal: HNO; 2002 Feb; 50(2):129-33. PubMed ID: 12080622.
    Abstract:
    BACKGROUND: beta-trace protein is an immunological marker for cerebrospinal fluid or inner ear fluids. We present two initial cases in which a beta-trace protein nephelometric assay provided immunological proof of perilymph in samples taken from the nasopharynx. PATIENTS AND METHODS: Two cases are presented of an acute vestibulocochlear disorder following stapedotomy. Fluid samples, taken from the nasopharynx, were investigated using beta-trace protein laser nephelometry. The samples were collected using Merocel tamponades, which were left in place over night. RESULTS: In both cases, the samples were positive for beta-trace protein. Tympanoscopy was performed and the oval window was closed. After tympanoscopy a partial recovery of the hearing impairment was observed. CONCLUSION: Using beta-trace protein, it seems to be possible to diagnose a perilymphatic fistula by noninvasive means.
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