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  • Title: [Observation on the degeneration and regeneration of the Meissner's corpuscles in the monkey's denervated fingers following sensory nerve implantation under electron microscope].
    Author: Li XY, Chen SZ, Li YJ.
    Journal: Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 1999 Jul; 13(4):193-8. PubMed ID: 12080795.
    Abstract:
    OBJECTIVE: To observe the degeneration and regeneration of the Meissner's corpuscles after implanted sensory nerve into the denervated monkey's fingers under electron microscope. METHODS: The two finger nerves of the monkey's fingers were denervated. Afterwards, one finger nerve was cut off, and the other was reimplanted into the denervated finger. After 1, 3, 5, 8 and 12 months, the finger skin was cut off and observed under electron microscope. RESULTS: The degenerative changes of nerve ending in Meissner's corpuscles were observed after 1 month of denervation, and the basic structure of the corpuscles had no obvious changes. After 3 months, the axons of corpuscles were disappeared, and the volume of corpuscles was shrunk. The basic structure of nerves was disappeared, and the lemmocyte and neurolemma plate were changed after 5 months. The collagen fibrils in the corpuscles were gradually increased in 8 months, the endoneurial structure and interneurial matrix were completely disappeared and replaced by collagen fibrils in 12 months. After 3 months of nerve implantation, unmyelinated nerve fibers were appeared and grew into the corpuscles. A part of corpuscles innervated in 5 months. Most of corpuscles innervated and myelinated nerve fibers were observed in 8 months. And in 12 months, corpuscles innervated to normal level. CONCLUSION: The implantative sensory nerve by means of reinnervating the original corpuscles and regenerating new corpuscles could innervate the degenerative Meissner's corpuscles.
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