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  • Title: Bioassay of prostaglandins in the presence of high concentrations of catecholamines.
    Author: Korbut R.
    Journal: Pol J Pharmacol Pharm; 1975; 27(6):631-6. PubMed ID: 1208236.
    Abstract:
    A column filled with activated aluminium oxide is incorporated into the bioassay system of Vane in which a rat stomach strip, a chick rectum and a rat colon are superfused in cascade. The absorbance of catecholamines by the column and the passage of prostaglandins through the column are almost 100%. This modification of Vane's technique enables PGE1, PGE2, PGF2, F2a to be estimated at concentrations as low as 0-5--1-0 ng/ml in the presence of catecholamines at a concentration as high as 50 ng/ml. Using this method we have demonstrated the release of small amounts (2 ng/ml) of an endogenous PGE-like substance from rabbit ear vessels contracted by an infusion of norepinephrine (500 ng/ml/min).
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