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  • Title: Single- and multistep selection study of the antipneumococcal activity of BMS-284756 compared to ciprofloxacin, levofloxacin, trovafloxacin and moxifloxacin.
    Author: Clark CL, Nagai K, Davies TA, Bozdogan B, Dewasse B, Jacobs MR, Appelbaum PC.
    Journal: Clin Microbiol Infect; 2002 Jun; 8(6):373-80. PubMed ID: 12084107.
    Abstract:
    Single- and Multi-step selection studies were used to test the ability of BMS-284756, ciprofloxacin, levofloxacin, trovafloxacin and moxifloxacin to yield resistant clones from 12 quinolone-susceptible and -resistant Streptococcus pneumoniae strains. Although all quinolones selected, to a greater or lesser degree, for resistant clones with mutations usually in parC or gyrA, BMS-284756 tended to select for resistant clones at a lower rate than other quinolones studied.
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