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  • Title: Lipid composition in postnatal methylazoxymethanol-treated swiss albino mouse cerebellum.
    Author: Jones M, Taylor W, Sculthorpe A.
    Journal: Proc Soc Exp Biol Med; 1975 Dec; 150(3):622-7. PubMed ID: 1208582.
    Abstract:
    Postnatal Swiss albino mice were treated with with methylazoxymethanol acetate (MAM) or saline and sacrificed at 25 days of age. Granule cell depletion resulted. Significant reduction in the cerebellar weight, protein, ganglioside sialic acid , cerebrosides, sulfatides, and phospholipids were documented. There was not, however, selective reduction of any component known to be associated with the synaptic structures. Specific association of cerebellar ganglioside with its granule cell population was not substantiated. Cerebroside/sulfatide ratios were not different in the two groups, indicating that significant alterations previously observed in spinal cord were not present in the cerebellum. It was concluded that the bulk of cerebellar granule cells and their synaptic connections could be deleted without affecting total ganglioside and phospholipid concentrations.
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