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  • Title: [The response to combined therapy of hepatic encephalopathy in patients with hepatic cirrhosis].
    Author: Maev IV, V'iuchnova ES, Lebedeva EG, Iakovenko EI, Dicheva DT.
    Journal: Klin Med (Mosk); 2002; 80(5):42-5. PubMed ID: 12087887.
    Abstract:
    Combined therapy with gepa-merz (L-ornitine-L-aspartate) and lactulose (a synthetic disaccharide) was given to 40 patients with hepatic encephalopathy and toxic hepatic cirrhosis in decompensation. Combination of gepa-merz with lactulose was effective in the above patients. Moreover, it is an optimal one as it has a double impact on ammonia toxicity which is a basic neurotoxin in pathogenesis of hepatic encephalopathy.
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