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  • Title: [Growth of insulin-producing beta cells. Perhaps a new way to treat type 1 diabetes].
    Author: Annerén C.
    Journal: Lakartidningen; 2002 May 23; 99(21):2394-5, 2398-9. PubMed ID: 12090167.
    Abstract:
    Insulin dependent diabetes mellitus (type 1-diabetes) results from a selective destruction of the insulin producing beta cells and a limited capacity of the remaining cells to regenerate in a compensatory manner. Increased knowledge of the factors involved in the regulation of beta-cell growth may lead to new ways of forming beta cells that in combination with selective immunosuppression could be used for treatment of type 1 diabetes. Physiological and pathophysiological conditions that induce beta-cell growth, different factors that have been implicated to regulate these processes and future perspectives concerning treatment of type 1 diabetes by expanding the beta-cell mass is discussed in this review article.
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