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  • Title: Levels of lipid peroxidation products in a chronic inflammatory disorder.
    Author: Deaney CL, Feyi K, Forrest CM, Freeman A, Harman G, McDonald MS, Petrie A, Shaw SJ, Stone TW, Stoy N, Darlington LG.
    Journal: Res Commun Mol Pathol Pharmacol; 2001; 110(1-2):87-95. PubMed ID: 12090359.
    Abstract:
    We have examined the plasma levels of the lipid peroxidation products 4-hydroxy-nonenal and malondialdehyde in a carefully controlled study of age and sex-matched subjects with rheumatoid arthritis in whom potentially confounding influences such as disease modifying anti-rheumatic drugs (DMARDs), self-medication and vitamin supplements were eliminated. The plasma concentrations of the antioxidants uric acid and vitamin E were also measured. The results reveal a strong and consistent inverse correlation between the levels of lipid peroxidation products in the plasma and erythrocyte sedimentation rate (ESR). There is no indication that vitamin E or urate function as the major antioxidant agent in arthritis, as has been suggested in more seriously affected patients. It is concluded that there is no evidence that vitamin E is more important, and urate less important as an antioxidant in mild arthritis. The correlation between lipid peroxidation and ESR suggests a more complex relationship than has been assumed.
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