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  • Title: [Normal erythropoiesis].
    Author: Winterhalter KH.
    Journal: Schweiz Med Wochenschr; 1975 Nov 22; 105(47):1558-62. PubMed ID: 1209217.
    Abstract:
    The organism has at least three different mechanisms for the modulation of oxygen supply to tissues: 1) respiratory-circulatory, 2) modification of oxygen dissociation of hemoglobin, 3) modification of oxygen transport capacity by increasing the volume of circulating red cells. The erythroid, granulocytic and thrombocytic cell lines originate from a common pluripotent stem cell. In the course of differentiation the erythroid precursor cell acquires the capability of responding to the humoral regulator of total red blood cell volume, erythropoietin. Furthermore, the ability develops to take up tightly bound iron from transferrin, to synthesize large amounts of hemin and to express the few structural genes for hemoglobin polypeptides preferentially. The effects of these phenomena are discussed in the framework of the erythron.
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