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  • Title: Flumequine in Atlantic salmon Salmo salar: disposition in fish held in sea water versus fresh water.
    Author: Sohlber S, Ingebrigtsen K, Hansen MK, Hayton WL, Horsberg TE.
    Journal: Dis Aquat Organ; 2002 Apr 24; 49(1):39-44. PubMed ID: 12093040.
    Abstract:
    14C-labeled flumequine was administered as a single oral (5 mg kg(-1), 86 microCi kg(-1)) or intravenous (5 mg kg(-1), 82 microCi kg(-1)) dose to Atlantic salmon Salmo salar held in sea water or in fresh water. The absorption, tissue distribution and elimination were determined by means of liquid scintillation counting and whole-body autoradiography. The drug was rapidly absorbed and extensively distributed in all groups of fish. Radiolabeled compound was present in blood and muscle for more than 8 wk in the freshwater groups. In the seawater groups, however, no radioactivity was detected in the blood and muscle after 4 d and 2 wk, respectively. It was concluded that flumequine was eliminated at a substantially higher rate from Atlantic salmon in sea water than in fresh water.
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