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  • Title: Properties of [3H]taurine release from crude synaptosomal fractions of rat cerebral cortex.
    Author: Placheta P, Singer E, Sieghart W, Karobath M.
    Journal: Neurochem Res; 1979 Dec; 4(6):703-12. PubMed ID: 120936.
    Abstract:
    The release of previously accumulated [3H]taurine and [14C]GABA from crude synaptosomal (P2) fractions isolated from rat cerebral cortex was studied using a superfusion system. The spontaneous efflux of [3H]taurine and [14C]GABA was stimulated by elevated concentrations of K+ (15--133 mM) in a concentration-dependent manner. This K+-stimulated relase of [14C]Gaba but not of [3H]taurine was enhanced in the presence of Ca2+. However, addition of 3 mM Ca2+ to the superfusion medium in the presence of the ionophore A 23187 resulted in a stimulation of the release of both [3H]taurine and [14C]GABA. These results are discussed in connection with the cellular localization of taurine in the central nervous system.
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