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  • Title: Alkaloids, amides and antispasmodic activity of Zanthoxylum hyemale.
    Author: de Moura NF, Morel AF, Dessoy EC, Zanatta N, Bürger MM, Ahlert N, Porto GP, Baldisserotto B.
    Journal: Planta Med; 2002 Jun; 68(6):534-8. PubMed ID: 12094298.
    Abstract:
    Two quinoline alkaloids, (-)-R-geilbalansine (1) and hyemaline (2), as well as aromatic amide, N-[2-(3,4-dimethoxyphenyl)-2-methoxyethyl)-2-methoxyethyl]benzamide (O-methylbalsamide) (3), were isolated as new natural products from the stem barks of Zanthoxylum hyemale, together with seven known compounds. Their structures were determined on the basis of spectroscopic data (IR, (1)H- and (13)C-NMR, MS). In addition, the antispasmodic activity of the crude extract of Z. hyemale and three other more abundant isolated compounds (4, 5 and 10) were studied in two different antispasmodic test models on isolated rat ileum and only the crude ethanolic extract presented antispasmodic activity.
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