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  • Title: Aceriphyllic acid A, A new ACAT inhibitory triterpenoid, from Aceriphyllum rossii.
    Author: Han JT, Kim HY, Park YD, Lee YH, Lee KR, Kwon BM, Baek NI.
    Journal: Planta Med; 2002 Jun; 68(6):558-61. PubMed ID: 12094307.
    Abstract:
    Two new triterpenoids along with three known ones, 3-oxoolean-12-en-27-oic acid (1), 3alpha-hydroxyolean-12-en-27-oic acid (2) and 3beta-hydroxyolean-12-en-27-oic acid (3), were isolated from Aceriphyllum rossii. The structures of the new compounds were determined to be a 3alpha,23-dihydroxyolean-12-en-27-oic acid (4) and a 3alpha,23-dihydroxyolean-12-en-29-oic acid (5) by spectroscopic and chemical methods; they were designated aceriphyllic acids A and B, respectively. Compounds 2, 3 and 4 remarkably inhibited the activity of ACAT.
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