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  • Title: Ferulagone: a new monoterpene ester from Ferulago thirkeana essential oil.
    Author: Başer KH, Demirci B, Demirci F, Hashimoto T, Asakawa Y, Noma Y.
    Journal: Planta Med; 2002 Jun; 68(6):564-7. PubMed ID: 12094309.
    Abstract:
    Essential oil obtained by micro-distillation and hydrodistillation of the endemic Ferulago thirkeana (Boiss.) Boiss. (Apiaceae) was analysed by GC/MS. An unknown component isolated from the essential oil was characterized by chromato-spectral techniques (1D-, 2D-NMR, HRMS, IR and UV) as (1 S)-2,6,6-trimethyl-4-oxobicyclo[3.1.1]hept-2-enyl(2 E)-2-methylbut-2-enoate (= ferulagone or 1-angeloyloxyverbenone) (1). Biological activities of the essential oil and the purified major component (1) were tested against various human pathogenic microorganisms resulting in moderate inhibition (62.5 - 125 microg/ml).
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