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  • Title: Nonrobertsonian translocation t(6;11) is associated with infertility in an oligoazoospermic male.
    Author: Pernice F, Mazza G, Puglisi D, Luppino MG, Frisina N.
    Journal: Fertil Steril; 2002 Jul; 78(1):192-4. PubMed ID: 12095514.
    Abstract:
    OBJECTIVE: To analyze an unusual nonrobertsonian translocation t(6;11) found in an infertile, oligoazoospermic, but otherwise apparently healthy man. DESIGN: Case report with review of the scientific literature. SETTING: Academic research environment. PATIENT(S): Infertile, oligoazoospermic, but otherwise apparently healthy man. INTERVENTION(S): Peripheral blood lymphocytes were obtained for karyotyping, and metaphases were studied by standard GBG, RBG, and CBG banding procedures. MAIN OUTCOME MEASURE(S): Sperm count, morphology, and GBG, RBG, and CBG banding. RESULT(S): A karyogram revealed a nonrobertsonian balanced translocation t(6;11) with breakpoints at 6q15 and 11p15, as shown by R-, G-, and C-banding. CONCLUSION(S): Physical contact of unpaired autosomal material with sex chromosomes, which leads to spermatogenic arrest, may be one of the factors that accounts for infertility in men with autosomal aberrations.
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