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  • Title: Double-blind placebo-controlled trial of secretin: effects on aberrant behavior in children with autism.
    Author: Carey T, Ratliff-Schaub K, Funk J, Weinle C, Myers M, Jenks J.
    Journal: J Autism Dev Disord; 2002 Jun; 32(3):161-7. PubMed ID: 12108617.
    Abstract:
    Secretin has been proposed as a treatment alternative for autistic spectrum disorders, but empirical support is lacking. A double-blind placebo-controlled study examined the effect of a single dose of synthetic human secretin on aberrant behavior. Parent and teacher data from the Aberrant Behavior Checklist for eight male children were analyzed for reliable change in a clinical replication series. By parent and teacher report, the majority of change occurred either on the placebo trial or reflected deterioration subsequent to secretin infusion. Repeated-measures multivariate analysis of variance results were similar. Results are consistent with other studies, suggesting that secretin may not be an effective treatment option.
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