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  • Title: [Neurotropic activity of lambertian acid and its amino derivatives].
    Author: Tolstikova TG, Voevoda TV, Dolgikh MP, Sorokina IV.
    Journal: Eksp Klin Farmakol; 2002; 65(2):9-11. PubMed ID: 12109303.
    Abstract:
    The neurotropic activity of the originally synthesized methyl lambertianate (II), as well as lambertianic acid (I) and three amino derivatives (III-V) was studied. All compounds exhibit equally low toxicity, but differ in the type of influence upon CNS. The most pronounced action was observed for esters II and V. Compound II exhibited a strong antidepressant effect with stimulating action. Introduction of the amino group led to an opposite tendency: compound V exhibited an antipsychotic and sedative (calming) effect upon CNS, without any anticonvulsant action.
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