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  • Title: Creutzfeldt-Jakob disease cluster in an Australian rural city.
    Author: Collins S, Boyd A, Fletcher A, Kaldor J, Hill A, Farish S, McLean C, Ansari Z, Smith M, Masters CL.
    Journal: Ann Neurol; 2002 Jul; 52(1):115-8. PubMed ID: 12112059.
    Abstract:
    Through the Australian National Creutzfeldt-Jakob Disease Registry, 6 pathologically confirmed sporadic cases were recognized over a 13-year period in persons who had been long-term residents of a moderate-sized rural city, whereas the expected number was 0.923. An extensive investigation could not find any point-source or case-to-case transmission links. This occurrence is highly statistically significant (p = 0.0027) when viewed in isolation and remains significant (p < 0.02) when only the cases that arose after the cluster was recognized were taken into account. However, a more conservative statistical analysis suggests that such a grouping could have arisen by chance in at least one population group of this size when the whole country is taken into consideration.
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