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  • Title: [Effect of compound 861 on tissue inhibitor of metalloprotenase 1 gene expression of HSC-T6 cells].
    Author: Yin C, Ma H, Wang A, Ma X, Jia J, Wang B.
    Journal: Zhonghua Gan Zang Bing Za Zhi; 2002 Jun; 10(3):197-9. PubMed ID: 12113678.
    Abstract:
    OBJECTIVE: To observe the in vitro effect of compound 861 (Cpd 861) on tissue inhibitor of metalloprotenase 1 (TIMP1) mRNA levels of HSC-T6 cell. METHODS: HSC-T6 cells were exposed in different concentrations of Cpd 861 (0.25~1.0 mg/ml) for 48 hours. The TIMP1 level was measured by the quantitative reverse-transcription polymerase chain reaction (RT-PCR). RESULTS: The TIMP1 mRNA levels of HSC-T6 cells at different concentrations of Cpd 861 were lower (2.50 0.71, 0.50 0.01, 0.11 0.03) than those of the normal control (3.78 0.67, P<0.05 or P<0.01). CONCLUSIONS: The antifibrotic mechanism of Cpd 861 is partly due to its downregulation on TIMP1 mRNA levels of HSC-T6 cells.
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