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  • Title: [Luteolin inhibits proliferation and collagen synthesis of hepatic stellate cells].
    Author: Zhao W, Liang C, Chen Z, Pang R, Zhao B, Chen Z.
    Journal: Zhonghua Gan Zang Bing Za Zhi; 2002 Jun; 10(3):204-6. PubMed ID: 12113680.
    Abstract:
    OBJECTIVE: To investigate the effect of luteolin on the proliferation and collagen expression of hepatic stellate cells. METHODS: The effect of luteolin on proliferation and collagen synthesis of hepatic stellate cells isolated from the liver of Wistar rats were determined by (3)H-TdR and (3)H-Pro, and procollagen gene expression was also detected by DIG-labeled gene probe and in situ hybridization. RESULTS: The proliferation and collagen synthesis were significantly and dose-dependently inhibited by luteolin when the concentrations reached 10 micromol/L and 20 micromol/L respectively (t=2.542, P<0.05; t=3.650, P<0.01). The type I, III procollagen mRNA expression was decreased by 25 micromol/L luteolin, in which the type I procollagen mRNA was reduced with statistical significance (x(2)=6.850, P<0.01). CONCLUSIONS: Luteolin inhibits the proliferation and collagen expression of hepatic stellate cells in vitro. It may have a preventive or therapeutic role in liver fibrosis.
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