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  • Title: Immunohistochemical detection of CD79a expression in precursor T cell lymphoblastic lymphoma/leukaemias.
    Author: Hashimoto M, Yamashita Y, Mori N.
    Journal: J Pathol; 2002 Jul; 197(3):341-7. PubMed ID: 12115880.
    Abstract:
    Twenty-three cases of precursor T cell lymphoid malignancies were examined with respect to CD79a expression. Immunohistochemical staining was performed on frozen tissue sections using a broad panel of antibodies and Southern blot analysis was undertaken using DNA probes encoding immunoglobulin heavy chain (IgH) gene and T-cell receptor (TCR) beta, gamma and delta genes. Twelve (52%) of the 23 cases examined demonstrated CD79a expression. IgH and TCRbeta, gamma and delta gene rearrangements were found in 5, 9, 12 and 20 cases, respectively. CD79a-positive neoplastic cells exhibited a phenotype and genotype characteristic of an early stage of T cell differentiation. Immunohistochemical staining was also performed on human thymus and thymoma to investigate the normality of CD79a expression, to discover that low-level expression of CD79a is common in thymocytes and thymoma-associated lymphocytes. These results suggest that CD79a is expressed weakly and transiently in immature T-lineage cells.
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