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  • Title: Baseline levels of plasma endothelin-1 (ET-1) and changes during transfusion in thalassemic patients.
    Author: Viprakasit V, Kankirawatana S, Akarasereenont P, Durongpisitkul K, Chotewuttakorn S, Tanphaichitr VS.
    Journal: Am J Hematol; 2002 Jul; 70(3):260-2. PubMed ID: 12118430.
    Abstract:
    We studied levels of plasma endothelin-1 (ET-1) in 25 beta-thalassemia/Hb E patients before and after blood transfusion. Baseline ET-1 levels in these patients were significantly higher than in normal controls (10.17 +/- 2.1 pg/mL vs. 8.9 +/- 2.0 pg/mL, P < 0.05). After blood transfusion, levels of plasma ET-1 tend to slightly increase during the first 24 hr but significantly decline at the 7th day to levels (8.01 +/- 1.7 pg/mL) which do not differ from those of controls. This study highlights a different alteration of plasma ET-1 in patients with beta-thalassemia compared to that of patients with sickle-cell anemia.
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